Protein name:
Beclin-1 ;
Alternative:
Protein GT197 ;Coiled-coil myosin-like BCL2-interacting protein ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with BCL2 and BCL2L1 (By similarity). Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 upregulates autophagy, while the one containing Rubicon downregulates autophagy (By similarity). Interacts with VMP1. Interacts with PIK3CB.
Function:
Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense.
Subcellular Location:
Cytoplasm
Golgi apparatus
trans-Golgi network membrane
Peripheral membrane protein
Interaction with ATG14 promotes translocation to autophagosomes.
Protein Attributes:
50:
MEGSKASSST | MQVSFVCQRC | SQPLKLDTSF | KILDRVTIQE | LTAPLLTTAQ |
100:
AKPGESQEEE | ANSGEEPFIE | TRQDGVSRRF | IPPARMMSTE | SANSFTLIGE |
150:
ASDGGTMENL | SRRLKVTGDL | FDIMSGQTDV | DHPLCEECTD | TLLDQLDTQL |
200:
NVTENECQNY | KRCLEMLEQM | NEGDSEQLQR | ELKELALEEE | RLIQELEDVE |
250:
KNRKVVAENL | EKVQAEAERL | DQEEAQYQRE | YSEFKRQQLE | LDDELKSVEN |
300:
QMRYAQMQLD | KLKKTNVFNA | TFHIWHSGQF | GTINNFRLGR | LPSAPVEWNE |
350:
INAAWGQTVL | LLHALANKMG | LKFQRYRLVP | YGNHSYLESL | TDKSKELPLY |
400:
CSGGLRFFWD | NKFDHAMVAF | LDCVQQFKEE | VEKGETRFCL | PYRMDVEKGK |
448:
IEDTGGSGGS | YSIKTQFNSE | EQWTKALKFM | LTNLKWGLAW | VSSQFYNK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
Chicken
ELISA Kit for Rat Beclin-1
ELISA Kit for Rat Beclin-1
ELISA Kit for Rat Beclin-1
ELISA Kit for Rat Beclin-1
ELISA Kit for Rat Beclin-1
ELISA Kit for Rat Beclin-1
CLIA Kit for Rat Beclin-1
CLIA Kit for Rat Beclin-1
CLIA Kit for Rat Beclin-1
CLIA Kit for Rat Beclin-1
CLIA Kit for Rat Beclin-1
CLIA Kit for Rat Beclin-1
Polyclonal Antibody for Rat Beclin-1
Polyclonal Antibody for Rat Beclin-1
Polyclonal Antibody for Rat Beclin-1
Polyclonal Antibody for Rat Beclin-1
Polyclonal Antibody for Rat Beclin-1
Polyclonal Antibody for Rat Beclin-1
Monoclonal Antibody for Rat Beclin-1
Monoclonal Antibody for Rat Beclin-1
Monoclonal Antibody for Rat Beclin-1
Monoclonal Antibody for Rat Beclin-1
Monoclonal Antibody for Rat Beclin-1
Monoclonal Antibody for Rat Beclin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Ovary .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
3.
"Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells."
Sauermann M.
,
Sahin O.
,
Sultmann H.
,
Hahne F.
,
Blaszkiewicz S.
,
Majety M.
,
Zatloukal K.
,
Fuzesi L.
,
Poustka A.
,
Wiemann S.
,
Arlt D.
Oncogene27:1320-1326(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH VMP1